Clinical inquiries. What's the best drug treatment for premature ejaculation?

نویسندگان

  • Michael G Mercado
  • Sandra L Kimmer
  • John R Holman
  • Gerri Wanserski
  • Vincent Lo
چکیده

antidepressants—specifically clomipramine, fluoxetine, paroxetine, and sertraline—are best and have been shown to improve symptoms of premature ejaculation (strength of recommendation [sor]: a, meta-analysis of randomized controlled trials [rcTs]). The topical application of prilocaine-lidocaine cream (trade name eMla) improves intravaginal ejaculatory latency time (IelT), but penile numbness and loss of erection may occur (sor: B, based on several small rcTs). There is no evidence that phosphodiesterase type 5 (PDe5) inhibitors—such as sildenafil (viagra), vardenafil (levitra), and tadalafil (cialis)—decrease instances of premature ejaculation in otherwise healthy men. There is limited evidence, however, that PDe5 inhibitors reduce symptoms of premature ejaculation for men with concomitant erectile dysfunction (sor: B, systematic review of rcTs of variable quality).

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عنوان ژورنال:
  • The Journal of family practice

دوره 57 3  شماره 

صفحات  -

تاریخ انتشار 2008